Amid the political uncertainties that continue to cloud the future of U.S. health care, one thing hasn’t changed: Patients, clinicians, health plans, payers, and policy makers are still striving to achieve better outcomes at lower costs. Given the heavy financial burden that health care is imposing on the country, the top priority should be fundamentally changing the way we care for high-cost, high-risk patients. Redesigning their care is a major way we can improve lives and sustainably reduce overall health care costs.