Pseudomonas aeruginosa - germ negative - Commonly found in environment - Found in 10% people flora of colon ( normally ) Produces 2 pigments : - Pyocanin : blue color - Pyoverdin ( flourescein) : a yellow green • Pathogenesis: - Endotoxin: sepsis and septic shock - Exotoxins : tissues necrosis , inhibits eukaryotic protein synthesis. - Enzymes: ( ex. Elastase and proteases ) - Pyocyanin : damage cilia and mucosal cells of respiratory tract . Infection: - nosocomial infection ( du hospital environment , 4th most common ) - Urinary track - Soft tissues - Pulmonary - Sever external otitis When disseminates it causes - Sepsis - Ecthyma gangrenosum ( # ) - Bone and joint infections - Endocarditis Is particularly concern of ; - Cyctic fibrosis - Burn patients - Hospitalised patients Treatment : -Antibiotics ( Ceftazidime, Meropenem, Tobramycin) - often a two-drug combination is employed. - Anti-peudomonal penicillins/cephalosporins(drugs) - Carbapenesms ( ex.aminoglycosides) (drugs) - Fluoroquinolones (drugs) Complications of antibacterial chemotherapy: • Development of drug resistance - Super infection - Hypersensitivity - Toxicity Drug mechanism of action and resistance : { Penicillins : - Inhibition of cell wall synthesis Resistance by > - by Cleavage by B-lactamase - mutation in penicillin-binding proteins - Mutation in porin proteins }

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